A new therapeutic agent for leukemia:clofarabine;
新型抗白血病药氯法拉滨
This article summarizes the process mechanism, pharmacokinetics,pharmacodynamics,clinical studies and safety profile of clofarabine.
氯法拉滨是第2代嘌呤核苷酸类似物,对患有难治性或复发性急性淋巴细胞白血病的1～21岁病人有显著疗效,是近10年来首个FDA批准的专门用于治疗儿童白血病的新药。
Benzoylated clofarabine was achieved by reacting 2-chloroadenine with 1-deoxy-1-.
氯法拉滨是一种核苷类似物，对多种实体瘤均有作用，对急性白血病的治疗尤为有效，是FDA首个专用于治疗儿童白血病的药物。