Objective To study the mutagenic action of antiepileptic drugs(AEDs), and find an effective way to prevent the mutagenesis induced by AEDs,by observing the effects of AEDs on serum folic acid(FA) level and sister chromatid exchange (SCE) frequency in epileptic children.
目的 通过检测外周血淋巴细胞姊妹染色体交换 (SCE)频率及血清叶酸 (FA)水平 ,研究抗癫药物 (AEDs)对机体的诱变作用及其对FA代谢的影响 ,寻求抗诱变作用的途径。
Objective: By observing the effects of antiepileptic drugs (AEDs) on serum folic acid (FA) level and sister chromatid exchange (SCE) frequency in epileptic children, we study the mutagenesis effect of AEDs, and lood for effective way to prevent chromosome damage or mutagenesis induced by carbamazepine (CBZ) and valproic acid (VPA).
目的：通过检测外周血淋巴细胞姊妹染色体交换（sister chromatid exchange， SCE）频率及血清叶酸（folic acid， FA）水平，来研究抗癫痫药物（antiepileptic drugs， AEDs）对机体的诱变作用及其对FA代谢的影响，并寻求抗诱变作用的途径。
Micronucleus test and sister chromatid exchange assay were adopted to study the genetic damages of Na_2SeO_3 at 0.
采用蚕豆根尖微核实验和姊妹染色单体交换实验,研究亚硒酸钠(0。
Methods: Frequency of sister chromatid exchanges (SCEs) was measured in lymphocytes of 8 victims of Tokyo sarin tragedy and 49 controls and statistical analysis was employed.
方法 :在沙林毒性气体事件中 ,检测了 8名暴露者、49名对照者的外周血淋巴细胞姊妹染色单体交换频率 (SCE)并进行了统计学分析。