Reteplase(rPA) is a recombinant non-glycosylated form of human tissue plasminogen activator(tPA) in which the molecule has been genetically engineered to contain 357 of the 527 amino acids of the original protein.
从人的黑素瘤细胞提取总RNA,进行RT-PCR,克隆了组织纤维溶酶原激活剂(tPA)基因,对其缺失突变,进一步克隆了溶栓药物瑞替普酶-reteplase(rPA)基因;以羊的β-乳球蛋白基因(BLG)作为调控序列,构建了瑞替普酶的乳腺表达载体BrPA。
The results of theoretical analysis indicate that ILLLIT surely can enhance the activity of plasminogen activator,which is advantageous to decreasing the aggregate degree of erythrocyte.
理论分析结果表明 ,ILLLIT提高了纤维蛋白溶酶原激活素的活性 ,有利于红细胞聚集指数的下
The results of theoretical analysis indicate that ILLLIT surely can enhance the activity of plasminogen activator, which is advantageous to decreasing the aggregate degree of erythrocyte.
理论分析表明 IL L LIT提高了纤维蛋白溶酶原激活素的活性 ,有利于红细胞聚集指数的下降。
Objective: To study the effects of genistein on the expression of urokinase-type plasminogen activator (uPA) and the activity of protein tyrosine kinase (PTK) in MDA-MB-453 cells, and explore the molecular mechanism of anti-angiogenesis in HER-2/neu-overexpressing breast cancer by genistein.
目的: 观察染料木黄酮(亦称三羟异黄酮,genistein,Gen)对MDA-MB-453乳腺癌细胞尿激酶型纤维蛋白溶酶原激活剂(urokinase-type plasminogen activator,uPA)表达及蛋白酪氨酸激酶(protein tyrosine kinase,PTK)活性的影响,探讨Gen抗HER-2/neu高表达乳腺癌血管生成的分子机制。
Objective To explore the inhibitory effect of genistein on oncogene HER-2/neu-overexpressing breast cancer xenograft tumors and its relationship with urokinase type plasminogen activator (uPA) expression.
目的 探讨三羟异黄酮(genistein)对原癌基因HER 2 neu高表达乳腺癌异种移植瘤的抑制作用及其与尿激酶型纤维蛋白溶酶原激活剂(urokinasetypeplasminogenactivator ,uPA)表达变化的关系。