RNA interference (RNAi) is a phenomenon of a double-stranded RNA (dsRNA) silenc ing the exression of the homologous gene and is a tremendous potential scient ific tool which could ultimately be used for genomic research and therapeutic pu rposes.
RNA干扰(RNAi)是双链RNA分子在mRNA水平上特异性封闭相应序列基因表达的过程,是一新兴的基因阻断技术。
Objective To investigate whether chemically synthesized double-stranded RNA(dsRNA) targeting epidermal growth factor receptor(EGFR) could induce gene silencing in non-small-cell lung cancer (NSCLC) cells, and to assess the degree of EGFR gene silencing and its effect on functional outcome.
目的探讨采用体外化学合成的针对表皮生长因子受体(EGFR)设计的双链RNA(doublestrandedRNA,dsRNA),是否能诱导肺非小细胞肺癌(NSCLC)细胞出现序列特异性基因沉默,及抑制EGFR基因表达后NSCLC细胞的生物学特征。
dsRNA-mediated Gene Silence and Antiviral Genetic Engineering;
双链RNA激发的植物基因沉默及其在植物育种上的应用
dsRNA Isolation Method and Research of Plant Virology;
双链RNA技术与植物病毒研究
In order to produce a marked effect in RNAi,21-25 nt siRNA,which is from dsRNA cutted by nucleinase,mediates and cuts homology mRNA.
它主要通过双链RNA(dsRNA)被核酸酶切割成21-25nt的小RNA(siRNA)发挥作用,由siRNA介导识别并靶向切割同源性靶mRNA分子而实现,需要有多种蛋白因子以及ATP参与,而且具有生物催化反应特征。
The title compound possesses novel hydrogen-bonded three-dimensional(3-D) network,in which unusual 1-D hydrogen-bonded organic double-stranded helical chains assembled from wrapping of two single-str.
该化合物在π-π堆积和氢键等超分子导向作用下组装成新颖的有机双链螺旋和三维氢键超分子结构。
Spectra of the Supramolecular Interaction of Neutral Red with Double-stranded DNA in a Neutral Medium;
中性介质中中性红与双链DNA作用的光谱(英文)