However, considerable concern has been expressed that this approach is prone to population stratification, which can lead to biased or spurious results.
文章对人群分层的检出及校正的方法和原理进行了阐述,包括基于核心家系的传递/不平衡检验(TDT)以及基于不相关基因组遗传标记的基因组对照(GC)和结构化关联(SA)等,并且对这几种方法进行了比较。
Recently,various statistical methods robust to population stratification were proposed for association designs studies, unrelated individuals to identify associations between candidate markers and traits of interest(both qualitative and quantitative).
目前,在关联研究中提出了许多针对解决控制人群分层的统计方法,这些方法几乎都是利用不相关个体来确定候选基因与遗传性状(包括数量与属性性状)之间的关联性的。