The mutations and clinical significances of gene c-abl in the ovarian tumors;
c-abl基因在卵巢恶性肿瘤中的突变及意义
Methods The amounts of Bcr-Abl protein were tested by Western blot.
结果NB能降低HL-60/Bcr-Abl细胞中Bcr-Abl的蛋白水平,NB使Bcr-Abl与Hsp90和Hsp70的结合减少,促进蛋白酶体降解Bcr-Abl蛋白,ALLnL处理后NP-40insoluble部分Bcr-Abl蛋白水平提高。
Aim To confirm the effects of Hsp90 inhibitor NB on STI571 resistant K562/G01 cells,and reveal the effect of combination of NB and STI571 on STI571 sensitive or resistant cells;to further clarify the relationship between growth inhibition and Bcr-Abl protein level and its kinase activity.
目的研究热休克蛋白90(Hsp90)抑制剂新生霉素(novobiocin,NB)对STI571耐药K562/G01细胞生长的抑制作用,并研究NB和STI571联合应用对STI571敏感和耐药细胞的作用,并进一步探讨该作用与Bcr-Abl蛋白水平和Bcr-Abl激酶水平的关系。
Analysis on Products of BCR/ABL Gene in WBC of Peripheral Blood and Its Application to Diagnosis of CML;
外周血白细胞BCR/ABL基因产物分析及其临床应用
Significance of the bcr Gene and bcr/abl Gene in the Occurrence and Progress of the CML;
bcr和bcr/abl基因在CML发生与发展中的意义
Effects of RNA Interference on bcr/abl Fusion Gene Expression in K562 Cell Line;
RNAi抑制bcr/abl融合基因表达及其对K562细胞的影响
An Example of Rare Chronic Lymphocyte Leukemia Accompanied by Re-acute Lymphatic Disease with Ph~1 and bcr/abl;
罕见的慢淋伴Ph~1阳性、bcr/abl融合基因阳性
Exploration into the restraint of siRNA on the apoptosis of K562 cells induce by BCR-ABL genes
siRNA抑制BCR-ABL基因诱导K562细胞凋亡的初探
Research on Immune Protective Mechanism of Gene Vaccines with Co-expressing Bcr-abl Fusion Gene Fragment and Mouse IL-7;
bcr-abl融合基因片段和鼠IL-7双表达基因疫苗的免疫保护机制研究
The Construct of CML Gene Vaccine and Establishment SP2/O Cell Lines Expressing bcr-abl Fusion Gene Fragment;
CML基因疫苗的构建及表达bcr-abl融合基因片段的SP2/O细胞系的建立
The Preliminary Study of BCR-ABL Fusion Gene Transgenic Mice with Tet-On System;
制备Tet调控BCR-ABL融合基因转基因小鼠的初步研究
Monitoring Bcr-Abl Fusion Gene by Real Time Quantitative PCR for Chronic Myelogenous Leukemia Patients after Haemopoietic Stem Cell Transplantation;
实时定量PCR监测CML患者造血干细胞移植后bcr-abl融合基因变化
Monitoring BCR/ABL Transcript Levels after Hematopoietic Stem Cells Transplantation by Real-time RT-PCR;
实时定量PCR监测造血干细胞移植后BCR/ABL融合基因的表达
Research of RT-PCR for Measurement of bcr/abl Fusion Gene mRNA Transcripts and the Value of Application on CML Clinical Treatment;
RT-PCR检测慢粒bcr/abl融合基因mRNA及临床应用价值的研究
Research of Real-time Quantitative Reverse-transcriptase Polymerase Chain Reaction (RQ-PCR) to Detect bcr/abl Fusion Gene in Chronic Myeloid Leukemia;
实时定量逆转录聚合酶链反应检测慢粒bcr/abl融合基因的研究
The Effect of Imatinib Mesylate Therapy on Ph Chromosome and Bcr/abl Gene Expression in Patients with CML
格列卫对慢性粒细胞白血病Ph染色体和bcr/abl基因表达的影响
Diagnostic and clinical significance of detecting bcr-abl gene in chronic myeloid leukemia
bcr-abl融合基因在慢性粒细胞白血病诊治中的意义
Detection of bcr/abl Fusion Gene by Dual Color-Dual Fusion Fluorescence In Situ Hybridization
双色双融合荧光原位杂交方法检测bcr/abl融合基因
Construction of genetically modified dendritic cell vaccine expressing bcr/abl fusion gene and inducing specific cytotoxic T lymphocytes to kill K562 cells in vitro
bcr/abl基因修饰树突细胞疫苗诱导CTLs杀伤K562细胞体外实验研究
Effects of lentivirus-mediated long term bcr/abl RNAi on biologic characteristics of human leukemia cell line K562
慢病毒介导bcr/abl基因RNAi对白血病K562细胞生物学特性的影响
FESH and Microarray Study on Apoptosis of K562 Cells Induced by BCR-ABL Gene Silence;
应用消减杂交和基因芯片技术研究BCR-ABL基因沉默诱导的K562细胞凋亡