Objective: To evaluate the safety and maximum tolerated dose of nolatrexed dihydrochloride in patients with malignant tumors.
最大耐受剂量(MTD)为920mg·m~(-2)·d~(-1)。
A phase Ⅰ clinical trial is primarily concerned with assessing the drug s safety,and one of the main objectives is to estimate the maximum tolerated dose of the dose.
在研究了新药第Ⅰ阶段临床试验最大耐受剂量估计方法的基础上,给出了基于启动规则的逐步连续重新评估方法(CRM),并与传统的Up-and-Down方法进行了模拟比较,结果表明:逐步CRM方法减少了受试人数,降低了受试者中毒人数的百分比,从而提高了该方法的临床可接受性。
Methods Twenty mice were used to study the acute toxic reaction with intragastric administration of Xinmaishu soup at the maximum tolerable dose(MTD),0.
结果小鼠按照最大耐受量即0。
[Object] Studying acute toxicity and maximum tolerable dose of Astragalus composition F3 new preparation.
[目的]研究黄芪成分F3新制剂的急性毒性和最大耐受量。
[Methods]①Singly-treated test:The oral exposure maximum tolerance dose was determined in mice according to the previous results of acute toxicity tests.
[方法]①单次给药实验 :在以往急性毒性实验的基础上 ,对昆明种小鼠口服一次给药 ,分别得到nano_Fe3O4、nano_Fe3O4_Glu的最大耐受量。
The maximum tolerance dose in mice was determined intravenously, intraperitoneally and intragastrically respectively.
采用尾静脉注射、腹腔注射、灌胃给药法测定小鼠对鲤鱼精巢ＤＮＡ的最大耐受量；采用全自动血细胞计数仪血象分析法检测鲤鱼精巢ＤＮＡ的安全性；采用磷酸三钠法检测血浆中尿酸含量；采用小鼠睾丸重量法检测性激素样作用。
Dose-Finding with Two Agents in Phase I Trials;
探寻两种制剂混合而成的药物的最大耐受剂量（MTD）
The Extended EWOC Method and Two-dimensional Isotonic Design of MTD-Finding Trials;
识别药物最大耐受剂量的推广EWOC方法和二维保序设计
Object] Studying acute toxicity and maximum tolerable dose of Astragalus composition F3 new preparation.
[目的]究黄芪成分F3新制剂的急性毒性和最大耐受量.
Experimental Study on Acute Toxicology of Salcalcitonin Buccal Spray in Mice
鲑鱼降钙素口腔喷剂的急性毒理与口腔黏膜吸收最大耐受量实验
Influence of Low-dose Naloxone on the Development of Morphine Tolerance in Rats;
小剂量纳络酮对大鼠吗啡耐受的影响
Effect of Low-dose Naloxone on Morphine Tolerance in Rats
小剂量纳洛酮对大鼠吗啡耐受的影响
Exploration of Ischemic Preconditioning Time for Inducing Rat Brain Ischemia Tolerance
诱导大鼠产生脑缺血耐受的时间剂量探讨
Effects of low dose naloxone on morphine-induced tolerance and dependence in rats
小剂量纳洛酮对吗啡致大鼠依赖和耐受的影响
As the addict's tolerance increases, he requires ever larger doses of the drug.
嗜毒者由於对药物的耐受性增加了, 因而需要更大剂量的毒品.
Experimental Study on Immune Tolerance Induced by a Short Course of Lower Doses of FK_(506) in Hepatic Cirrhosis Rats after Liver Transplantation;
短期应用小剂量FK_（506）诱导肝硬化大鼠肝移植免疫耐受的实验研究
The tolerance of high-dose methotrexate(HD-MTX) in the treatment of the children with acute lymphoblastic leukemia
大剂量甲氨蝶呤治疗小儿急性淋巴细胞白血病临床耐受性研究
Conclusions: The erythromycin in small dose can improve the feeding tolerance of immature babies.
结论:小剂量红霉素能提高早产儿喂养耐受性。
Observation on therapeutic effect of erythromycin in small dose on premature babies with feeding intolerance
小剂量红霉素治疗早产儿喂养不耐受疗效观察
Changes in the maximal oxygen uptake during endurance training;
最大摄氧量在耐力运动训练中的变化
The maximum load dosage was 160.89 rad.
超剂量照射人员中,最大累积吸收剂量为160.89拉德。
The maximum power： what the card can endure, be equal to Precision Alumina Ceramic( Alumina95%). High-power laser can make the card display bright green.
最大功率：可耐受精密陶瓷所能耐受的大功率激光，较大功率的红外激光可转换为明亮的绿光。
Objective: To evaluate the effects of small dose of insulin on feeding intolerance in preterm infants.
目的:评估小剂量胰岛素治疗早产儿喂养不耐受的疗效。
Low-dose ErythromycinVery in Treatment of Low Birth Weight Infants with Feeding Intolerance:Clinical Observation of 67 Cases
小剂量红霉素治疗极低体重儿喂养不耐受67例疗效观察