After the optimized test of temperature and solvent, ethyl propionylpyruvate had a yield above 90% and product content above 95% in ethyl ether below 5 ℃.
在合成中间体丙酰丙酮酸乙酯中,对反应温度和反应溶剂进行了优化试验,发现用乙醚作溶剂在5℃以下时,反应收率和中间体质量分数分别达到90 %和95 %以上。
After the optimized test of temperature and solvent, ethyl propionylpyruvate was produced in ethy1 ether at 5 ℃ of a yield above 90%.
探讨了Knorr环合法制备1-甲基-3-乙基-5吡唑酸乙酯的工艺;合成丙酰丙酮酸乙酯中,对反应温度和反应溶剂进行了优化试验,发现用乙醚作溶剂在5℃以下时,反应收率和中间体含量分别达到90%和95%以上。
A simple TLC method for monitoring the synthetic process of 3-bromo-ethyl levulinate is reported,and the reaction condition is optimized.
用薄层色谱法监测溴素溴化乙酰丙酸乙酯生成3-溴乙酰丙酸乙酯的反应过程,优化了反应条件,方法简单,快速,准确。
Methods: Starting from ethyl 3-oxopentanoate,JTT-20993 was obtained via a series of chemical reactions including bromina tion,cyclization,alcoholization,methanesulfonization and condensation.
方法:以丙酰乙酸乙酯为起始原料,先溴化得到4-溴丙酰乙酸乙酯,然后与苯甲酰胺回流环合得到2-(5-甲基-2-苯基-4-(？)唑基)-乙酸乙酯,再还原成醇,并甲磺酰化,得到中间体2-(5-甲基-2-苯基-4-(?)唑基)-乙醇甲磺酸酯,最后与4-羟基苄基丙二酸二甲酯缩合,得到目标物JTT-20993。
It was started from ethyl 3-oxopentanoate,and was brominated,and then ethyl 4-bromo-3-oxopentanoate was produced,which cyclized with benzamide at reflux in toluene and afforded to ethyl 2-(5-methyl-2-phenyl-4-oxazolyl)acetate,then was reduced with lithium aluminum hydride and 2-(5-methyl-2-phenyl-4-oxazolyl)ethanol was gained.
以丙酰乙酸乙酯为起始原料 ,先溴化得到 4 溴丙酰乙酸乙酯 ,再在甲苯中与苯甲酰胺回流环合得到 2 (5 甲基 2 苯基 4 唑 ) 乙酸乙酯 ,最后经氢化铝锂还原 ,得到目标杂环中间体 2 (5 甲基 2 苯基 4 唑 ) 乙醇。
Studies on the Synthesis of 3-Bromo-Ethyl Levulinate by TLC
薄层色谱法研究乙酰丙酸乙酯溴化反应
The Regioselective Study of Ethyl Levulinate and Benzaldehyde's Nucleophilic Addition Reaction
乙酰丙酸乙酯和芳醛加成反应区域选择性的研究
acetoacetic ester
乙酰醋酸酯[乙酯]
ethyl acetoacetic ester
乙基乙酰乙酸酯[乙酯]
acetyl triallyl citrate
乙酰柠檬酸三烯丙酯
Calorimetric Investigation into Diethylacetamidomalonate (C_9H_(15)NO_5)
乙酰氨基丙二酸二乙酯的量热学研究
ethyl sodio acetoacetic ester
乙基钠代乙酰乙酸酯
o-acetyl-triethyl citrate
邻乙酰柠檬酸三乙酯
methoxyethyl acetyl ricinoleate
乙酰蓖麻酸甲氧基乙酯
Study on Synthesis of 5-Aminolevulinic Acid Based on the Levulinic Acid
乙酰丙酸合成5-氨基乙酰丙酸的研究
Ethylene/ethyl acrylate EEA
乙烯/丙烯酸乙酯共聚物
Reactions of Acylthiobenzothiazole with Ethyl Acetoacetate, Diethyl Malonate and Pentane-2, 4-dione
酰硫基苯并噻唑与丁酮酸乙酯、丙二酸二乙酯及戊二酮的反应
BPO INITIATED GRAFTING COPOLYMERIZATION OF VAc ON ETHYLENE PROPYLENE RUBBER
过氧化苯甲酰引发乙丙橡胶膜接枝乙酸乙烯酯研究
Cyclization of Diethyl-2-Acetamido-2-[2-(4-Octylphenyl)Ethyl]Malonate;
2-乙酰氨基-2-[2-（4-正辛基苯基）乙基]丙二酸二乙酯的环合反应
methyl-malonic ester
甲基丙二酸酯[二乙酯]
Cesium Base Promoted Alkylation, Arylthiolation and Arylselenolation of Diethyl Malonate, Ethyl Acetoacetate;
铯碱作用下丙二酸二乙酯、乙酰乙酸乙酯的烃基化、芳硫（硒）化反应研究
heparan sulfate sulfatase
硫酸乙酰肝素硫酸酯酶
Preparation of α-Angelica Lactone by Integrated Reaction-Separation Process from Levulinic Acid
乙酰丙酸反应分离一体化制α-当归内酯