As one of the key-enzymes in folic acid metabolic pathway, Folylpolyglutamate synthetase (FPGS) content and activity directly associated with the effects of MTX.
背景:氨甲蝶呤(Methotrexate,MTX)是许多叶酸途径抗肿瘤药物的前体,存在L-(+)-MTX和D-(-)-MTX 2种形式的对映体,广泛应用于淋巴瘤、急性白血病和肺癌等多种肿瘤的治疗,作为MTX代谢途径中的关键酶之一的细胞内叶酰聚谷氨酸合成酶(folylpolyglutamate synthetase,FPGS),其含量和活性直接与MTX作用效果相关,已成为当今研究的热点,但有关FPGS定量检测的报道甚少。
Cloning and Expression of N-acetylglutamate Kinase Gene from Corynebacterium Crenatum;
钝齿棒杆菌N-乙酰谷氨酸激酶编码基因argB的克隆表达研究
Expression Profiling of Intestinal N-Acetylglutamate Synthase in Pre-Weaned Tibetan Suckling Piglets
哺乳期藏猪肠道N-乙酰谷氨酸合成酶在哺乳期的表达特性
Expression,Purification and Biochemical Characterization of N-Acetylglutamate Kinase from Streptococcus mutans,the Leading Pathogen of Human Dental Caries
致龋变异链球菌N-乙酰谷氨酸激酶的表达、纯化和生化特性研究
Synthesis of N-acetyl-aspartyl-glutamate-a kind of nerve dipeptide
神经二肽N-乙酰天门冬氨酰谷氨酸的合成
Effect of Glutathione and N-acetylcysteine Against Glutamate Cytotoxicity;
谷胱甘肽及N-乙酰半胱氨酸抗谷氨酸细胞毒性研究
Aspartic acid An AMINO ACID formed by transamination, in which the amino group of dlutamic acid is transferred to oxaloacetic acid.
天冬氨酸：由转氨基作用形成的一种氨基酸，谷氨酸的氨基基团被转移到草酰乙酸中。
The Enzymatic Synthesis of γ-L-glutamyl-L-tyrosine with γ-glutamyltranspeptidase
γ-谷氨酰转肽酶法合成γ-L-谷氨酰-L-酪氨酸
Study on Synthesis of 5-Aminolevulinic Acid Based on the Levulinic Acid
乙酰丙酸合成5-氨基乙酰丙酸的研究
glutamate oxaloacetate transaminase
谷氨酸 草酰醋酸氨基移转酶
acetylaminohydroxy-phenylarsonic acid
乙酰氨基羟－苯胂酸
uramildiacetic acid 2-
氨基丙二酰脲二乙酸
3-acetamido-4-hydroxy-benzenearsonic acid
３－乙酰氨－４－羟苯砷酸
aminolevullnate dehydratase
σ-氨基乙酰丙酸脱水酶
N-hydroxyacetylneuraminic acid
Ｎ－羟乙酰神经氨酸
Study on Acetylcholine Potentiating Glutamate Neuronal Excitotoxicity and Its Mechanism of Receptors during Cerebral Ischemia
脑缺血时乙酰胆碱加强谷氨酸的神经兴奋毒性及受体机制研究
Effect of the Glyoxylate Cycle on L-Glutamate Synthesis by Corynebacterium Glutamicum;
谷氨酸棒杆菌的乙醛酸循环与L-谷氨酸合成
Enzymatic Synthesis of γ-L-Glutamyl-L-Cysteine with Immobilized γ-Glutamyltranspeptidase
固定化γ-谷氨酰转肽酶催化合成γ-L-谷氨酰-L-半胱氨酸
diminazene aceturate
重氮氨苯脒乙酰甘氨酸盐