In addition,the locomotor activity test was used to detect the change of locomo.
方法:采用经典的行为绝望抑郁模型,即小鼠悬尾实验和强迫游泳实验,观察减压特号急性给药对应激小鼠绝望不动时间的影响;同时观察减压特号对小鼠自主活动的影响,荧光分光光度法测定减压特号对小鼠脑内单胺氧化酶活性的影响。
The experiment was divided into two parts:1) comparison between the dose(60,120,240 mg/kg)and temporal features of the effects of modafinil and its two derivatives on locomotor activity of mice;2) Observation of the stimulating effects of modafinil(120 mg/kg.
结果Mod可剂量相关地提高小鼠自主活动 ,以 1 2 0mg/kg效果最佳 ;氯化有增强其作用的趋势、而甲基化使作用降低。
Effect of anti-kindled drugs on spontaneous activity of mice;
抗点燃药物对小鼠自主活动的影响
METHODS Using the sedative and hypnotic experiments to observe the open-field activity and the spontaneous activity after mice were intraperitoneally injected 320,160,80 mg·kg-1 of ferulic acid and 2 000,1 000,500 mg·kg-1of ligustrazine,measuring the changes of hypnotic action induced with pentobarbital in subthreshold.
kg-1川芎嗪,观察用药前后对小鼠旷场行为和自主活动的影响,及其协同戊巴比妥钠对小鼠的催眠作用影响。
Methods The changes of spontaneous activity and open-field activity before and after treatment,and its hypnotic action of subthreshold pen- tobarbital dosage by peritoneal injection of LEO of 6,3 and 1μ1.
目的研究川芎挥发油对小鼠自主活动及对阈下剂量戊巴比妥钠催眠作用的影响。
Through the stereotaxis instrument toluene was injected into the ventricle of mice s brain,3 d,5 d,1 w,2 w and 3 w after operation,observe the change of their autonomic activities and the ability of study and memory.
运用脑立体定位仪,将甲苯直接注入小鼠脑室,观测注射后3d、5d、1w、2w及3w小鼠自主活动次数及水迷宫潜伏期的变化。
Methods: The central nervous system effects and the effect on the subthreshold hypnotic dosage of Pentobarbital Sodium of Qingkailing Injection were observed on the mice by observing the general ethological index and the changes of the autonomic activities;and the effects .
方法:尾静脉注射给予小鼠不同剂量注射用清开灵冻干粉,或同时腹腔给予阈下催眠剂量的戊巴比妥钠,观察小鼠一般行为学指标和自主活动的变化,以及对戊巴比妥钠阈下催眠剂量的影响;给予麻醉犬不同剂量清开灵冻干粉观察该药对血压,心电图以及呼吸指标的影响。
The research observed the effect of Naolingsu Capsule on the central nervous system with independent activity,hypnosis of pentobarbital sodium of threshold dose and subthreshold dose,and reaction of tonic convulsion under electric stimulation in mice.
通过小鼠自主活动、戊巴比妥钠阈剂量及阈下剂量催眠作用及电刺激强直性惊厥反应,观察脑灵素胶囊对中枢神经系统的影响。
Results Extracellular DA,DOPAC and HVA levels in the PFC and the locomotion numbers of mice were signific.
方法通过微透析结合高效液相色谱电化学法(HPLC ECD)检测DA及其代谢产物,同时监测小鼠的自主活动。