- It has a serious flaw!
-它有严重的缺陷!
The two bone-grafting techniques currently available have serious limitations.
现行的两种骨移植法有严重的缺陷。
Your English essay is seriously flawed.
你的英语作文有严重的缺陷（错误很多）。
raised serious objections to the proposal; the plan has a serious flaw.
对这一建议提出了尖锐的反对；这个计划有严重的缺陷。
So,the reflux happens at filling stage means that the anti-reflux structure is damaged more severely than that happens only at voiding state.
充盈期出现返流，提示抗返流结构存在严重的缺陷。
disabling mental condition
心智机能上的严重缺陷
At present our Party activities leave much to be desired.
目前，我们党的生活是有严重缺陷的。
Of course, there are a variety of reasons for this.
当然，造成严重缺陷的原因有多种。
Serious design flaws present that compromise product quality.
有严重的设计缺陷危及产品质量。
The manufacturers have called in some cars with serious faults.
厂商已收回一些有严重缺陷的汽车。
Our transport system has a serious design fault.
我们的运输系统设计有个严重缺陷。
Exemptions from military service shall be granted to persons unfit for it due to serious physical defects or serious deformities.
有严重生理缺陷或者严重残疾不适合服兵役的人，免服兵役。
They should know that there has been gross neglect and deficiency in our defences;
他们应该知道我们的国防有严重疏忽和缺陷；
a person with a visual handicap severe enough to leave them unemployable.
一个有严重视力缺陷而几乎看不见东西的人。
a rare but serious syndrome of childhood characterized by withdrawal and lack of social responsiveness or interest in others and serious linguistic deficits.
罕见但严重的儿童自闭症:呈现自闭,缺乏社交反应和有严重的语言缺陷。
Deafness is a serious limitation in this job.
做这个工作耳聋是个严重缺陷。
Any departure from the foregoing points should be considered a fault and the seriousness of the fault should be in exact proportion to its degree.
任何的前述各点的背离都被看作是缺陷，缺陷的严重程度必须精确的被衡量。
The economy has dipped into a serious recession
经济已陷入严重的衰退。