The asymmetric borohydride reduction of prochiral ketones by different kinds of chiral phase transfer catalysts under the condition of S L phase transfer catalysis was explored and the influence of different solvents, temperatures and catalysts to the reaction was investigated.
在固—液相转移 (PTC)条件下 ,研究了前手性酮的不对称硼氢化还原 ,对不同的催化剂、反应溶剂、温度及反应底物对不对称诱导的影响进行了调查 ,结果表明固—液 PTC比液—液 PTC具有更高的光学产率。
Asymmetric borane reduction of prochiral ketones is a good process to the synthesis of enantiomerically enriched secondary alcohols.
硼烷对前手性酮的不对称还原是合成手性仲醇的重要方法。
Using 10 as the catalyst, six prochiral ketones were reduced enantioselectively with borane and the results were compared with those with 1,1- diphenylprolinol as catalys.
用10催化6种前手性酮的不对称硼烷还原反应,其结果与(S)-二苯基脯氨醇催化的同一反应的结果进行了对比。
Two groups of catalysts,(S)-diphenylprolinol(1) and(2S)-diphenylhydroxymethyl-(4S)-phenoxy-pyrrolidine(2),(R)-2-amino-1,1-diphenyl-3-(2-naphthyl)-1-propanol(3) and(R)-1-(1′-amino-2′-naphthylethyl)-cyclopentanol(4),were prepared and used in the enantioselective reduction of six prochiral ketones with borane.
以合成的两组手性催化剂,(S)-二苯基脯氨醇(1)和(2S)-(二苯基羟甲基)-4苯氧基-四氢吡咯(2),(R)-2-氨基-1,1-二苯基-3-(2′-萘基)-1-丙醇(3)和(R)-1-(1′-氨基-2′-萘乙基)-环戊醇(4),用于六种前手性酮的不对称硼烷还原反应,比较其还原结果,发现(2)的性能优于(1),(4)优于(3)。
Asymmetric reduction of prochiral ketones using oxazaborolidines has become one of the standard tools for the synthetic chemist, allowing access to enantiomerically enriched secondary alcohols with excellent enantiomeric excess that may seve as the chiral ligands for enantionselectivity synthesis and highly useful intermediates in the sy.
手性噁唑硼烷催化前手性酮的不对称还原反应已成为合成化学家的重要手段之一,这种方法获得的手性仲醇具有较高的ee 值,它们可作为不对称合成中的手性配体及活性物质、天然产物和药物的手性中间体。
Particularly, general approaches to the formation of asymmetric glycerophospholipid skeletons by utilizing stereospecific reactions and chiral precursors are dis-- cussed.
着重讨论了利用不对称反应和手性前体合成不对称甘油型磷脂骨架的方法。
Analysis of complications of anterior approaches to the thoracolumbar spine in 5 cases;
5例胸腰段脊柱前路手术并发症分析
Observation of therapeutic effects of treating lower cervical spine fracture and dislocation on 30 cases by anterior approach
颈前路手术治疗下颈椎骨折脱位30例疗效观察
[Objective] To discuss the results of anterior approach and small-incision for old thoracolumbar spinal fracture surgery assisted by thoracoscope.
目的探讨胸腔镜辅助下小切口前路手术治疗陈旧性胸腰段脊柱骨折的疗效。
The Asymmetric Catalytic Reduction of Prochiral Ketones Catalyzed by Chiral Oxazaborolidine;
手性噁唑硼烷催化前手性酮的不对称催化还原反应
Theoretical Studies on the Stereoselectivities in the Enantioselective Reductions of Prochiral Ketones Catalyzed by Oxazaborolidines;
噁唑硼烷催化前手性酮不对称还原反应立体选择性的理论研究
Study on Catalytic Asymmetric Transfer Hydrogenation and Allylic Vinylogous Michael Addition Reactions;
不对称催化的前手性酮转移氢化反应和烯丙位Michael加成反应研究
Advances in Asymmetric Reduction of Prochiral Ketones Catalyzed by Diphenylprolinol and Its Derivatives
二苯基脯氨醇及其衍生物对前手性酮的不对称催化还原研究进展
Synthesis of Chiral Multioxazolines and Applications in Rh(Ⅲ)-Catalysed Asymmetric Hydrosilylation of Potential Kotone;
手性多噁唑啉的合成及其在Rh（Ⅲ）催化的前手性酮的不对称硅氢化反应中的应用研究
Design and Synthesis of New Chiral Amino Alcohols and Their Application in the Asymmetric Borane Reduction of Prochiral Ketones;
手性氨基醇类催化剂的设计合成及其在硼烷对前手性酮不对称还原反应中的应用研究
Enantiomers Separation of Ketoprofen Sustained Release Capsules
奥丁尼酮洛芬缓释胶囊中酮洛芬的手性拆分
Synthesis of Novel Chiral Spirocycle Acetal (Ketal) Compounds;
新型手性螺环缩醛（酮）化合物的合成
Application of Ketamine Combined with Tramadol in the Preemptive Analgesia for Laparoscopic Cholecystectomy;
氯胺酮联合曲马多用于腹腔镜手术超前镇痛
EFFECTS OF ARTIFICIAL ABORTION AND CLINICAL NURSING KNOWLEDGE IN TAKING MIFEISITONE BEFORE OPERATION
人流前服用米非司酮对手术效果的观察与探讨
Optical Resolution of Rosiglitazone and Pioglitazone by High-performance Liquid Chromatography Using Chiral Stationary Phase
高效液相色谱法对手性药物罗格列酮与吡格列酮的拆分
Studies of Chiral N-oxide Catalize Asymmetric Strecker Reaction of Ketoimines;
手性氮—氧化物催化的酮亚胺Strecker反应研究
Studies on the Catalytic Asymmetric Cyanosilylation of Ketones by Chiral Amino Acid Salts;
手性有机酸盐催化酮的不对称硅腈化反应研究
Study on Asymmetric Transfer Hydrogenation of Acetophenone in Water;
苯乙酮不对称还原为手性α-苯乙醇的研究
The Study of Asymmetric 1,3-Dipolar Cycloaddition Catalyzed by Chiral Oxazaborolidinone;
手性噁唑硼烷酮催化1，3-偶极环加成反应的研究
Direct Chiral Separation of Propafenone Enantiomers by RP-HPLC Using Chiralpak AD-RH
CHIRALPAK AD-RH手性柱直接拆分普罗帕酮对映体
The Aldo-keto Reductase Superfamily and Its Application for Chiral Alcohol Asymmetric Synthesis
醛酮还原酶及其在不对称合成手性醇中的应用
Adrenal-sparing Surgery in Patients with Aldosterone-Producing Adenomas
保留肾上腺手术治疗醛固酮瘤的可行性