Increasingly it is being recognized that the combine administration of selective ligands (one-target drugs) and designed multiple ligands can modulate a balance of several targets and provide a superior therapeutic effect and side effect profile compared with the action of.
本文从最近有关多靶点配体药物分子设计的文献中选取了大量的实例,从不同的角度对比分析了单靶点药物的美中不足,以生动的实例介绍了多靶点药物的优势,详细介绍了多靶点配体药物分子设计的方法和需要优化的参数,综述了多靶点药物的研发和应用现状和研究进展。
rotating multitarget stereotactic apparatus
转盘式多靶点立体导向器
Treatment of Schizophrenia with Intracerebral Multi-Targets Stereotactic Lesions
立体定向脑内多靶点联合毁损治疗精神分裂症
Multi-target Treatment of Mental Retardation by Stereotactic Techniques-a Study of 16 Cases;
立体定向下选择性多靶点治疗精神发育迟滞16例报告
Follow-up Study of Multiple Target and Stereotactic Operation on Patients with Refractory Obsessive-compulsive Disorder
立体定向多靶点联合毁损术治疗难治性强迫症的随访研究
Therapeutic efficacy of multiple target and stereotactic operation on patients with affective disorder
立体定向多靶点联合毁损术治疗情感障碍患者的疗效观察
Study on Hepatocyte-tageted Gene Transduction of Chitosan in Vivo;
壳聚糖介导肝靶向性基因转导的体内实验研究
Study on an inductive steering speed sensor
电磁感应式转向盘转速传感器的研究
multi-vane diffuser
多导向叶片式扩压器
Study on Pathological Changes and Ultrastructure of Stereotactic Poly-target Biopsy Specimens Obtained from Peritumoral Edema Area in Intracranial Tumors;
颅内肿瘤瘤周水肿区立体定向多靶点活检组织病理及超微结构研究
integral hydraulic power steering gear
整体式液压助力转向器
Establishment of experimental aminal model of RNAi in vivo using lentivirus-siRNA vector system targeting TFAM
靶向线粒体转录因子A大鼠活体RNA干扰实验动物模型的建立
The Pharmaceutical Research on Antibody-conjugated Long-circulating Cationic Liposomes Mediating DNA and siRNA Transfection
抗体靶向的长循环阳离子脂质体介导DNA和siRNA转染的制剂学研究
Study on the Targeted Therapy of Tumour by Retroviral Vector-mediated Thymidine Kinase Gene;
逆转录病毒载体介导的胸苷激酶靶向治疗肿瘤的研究
steering wheel clearance checking scale
转向盘自由间隙测量器
Preparation and in Vitro Assay of Microbubbles Targeting Solid Carcinoma by KDR with Biotin-avidin System
以KDR为靶点的靶向脂质体超声造影剂的制备及体外靶向实验研究
The steering wheel is mounted on a steering shaft that extends into the steering gear.
转向盘安装在转向轴上,转向轴延伸至转向器。
Development of Novel Polymeric Microbubble with Matrix Metalloproteinase-2 Targeting Potential
新型多聚体微泡介导的基质金属蛋白酶-2靶向显像实验研究
Experimental study of the targeting recombinant adenoviral vector in reversing the mdr hepatocarcinoma cells
靶向重组腺病毒载体逆转肝癌细胞多药耐药的实验研究