Purpose To build a three dimensional structure activity relationship model of the title compounds and gain further insights into requirements for potential nonsteroidal progesterone receptor agonists.
目的 建立非甾体类孕酮受体激动剂5-亚苄基-1,2-二氢-5H-苯并吡喃并[3,4-f]喹啉衍生物的三维 定量构效模型,为设计高效的非甾体类孕酮受体激动剂提供理论依据。
3-(3-Chloro-1,2,5-thiadiazol-4-yl)pyridine,which is a key intermediate of selective M1 receptor agonist xanomeline,was synthesized from 3-pyridine carboxaldehyde,sodium cyanide,and sulfur chloride.
以3-吡啶甲醛为原料,与氰化钠、一氯化硫反应合成选择性M1受体激动剂占诺美林的关键中间体3-(3-氯-1,2,5-噻二唑-4-基)吡啶,目标化合物的结构经1H-NMR谱确证。
In this paper, the recent research progress in drugs for treatment of AD and their mechanisms are reviewed, including AChE inhibitor,M1 receptor agonist,antioxidants,nerve growth factor,calcium regulator and so on.
综述了近5年来治疗AD药物的研究进展,根据作用机制的不同对临床应用的抗AD和有促智活性的药物进行分类详述,主要分为乙酰胆碱酯酶抑制剂等改善胆碱功能的药物、M1受体激动剂、抗氧化药物、消炎镇痛药物、抑制Aβ蛋白形成的药物、神经生长因子、钙调节剂、晚期糖基化终产物(AGE)抑制剂以及中药复方等几类。
The method for determination of β2-agonists (salbutamol, terbutaline, cimaterol, cimbuterol, ractompamine, clenbuterol, bromobuterol, isoxsuprine, mabuterol, mapenterol, bromclenbuterol) residues in liver and meat of pig was developed by HPLC/MS-MS.
建立了同时检测11种β2-受体激动剂物质(包括沙丁胺醇、特布它林、塞曼特罗、塞布特罗、莱克多巴胺、克仑特罗、溴布特罗、苯氧丙酚胺、马布特罗、马贲特罗、溴代克仑特罗)在猪肉及猪肝脏中残留量的液相色谱-串联质谱(HPLC/MS-MS)方法。
A delicate method has been developed for the simultaneous determination of 23 β2-agonists and 5 β-blockers illegal drugs in muscle tissues by high performance liquid chromatography-linear ion trap mass spectrometry using isotope dilution technique.
利用高效液相色谱-线性离子阱质谱(HPLC-ITMS)以同位素稀释技术测定了肌肉组织中23种β2-受体激动剂及5种β-阻断剂。
Determination of β-agonists in Pig Urine by HPLC-MS/MS;
高效液相色谱-串联质谱法检测猪尿中四种β-受体激动剂残留的研究
A reasonable and reproducible liquid chromatography-mass spectrometry(LC/MS) for detecting β-agonists was developed.
建立了合理、可靠的液相色谱-质谱联用测定β-受体激动剂的方法。
The separation ofβ-agonists was performed.
建立了动物源食品中特布他林、西马特罗、沙丁胺醇、非诺特罗、氯丙那林、莱克多巴胺、克仑特罗、妥布特罗和喷布特罗等9种β-受体激动剂残留检测的超高效液相色谱-串联质谱方法。
High Throughput Screening of D1-like Receptor Agonist and Klotho Promoter Activator;
D1样受体激动剂和klotho启动子激活剂的药物筛选
Analysis of Mechanisms to I-/α_2-receptor Agonists on Rabbit Sinoatrial Node and Vascular Purinergic Nerve
咪唑啉受体/α_2-受体激动剂的心血管电生理效应
Advance on the Research on and Development of β_3-Adrenoceptor Agonists
β_3-肾上腺素受体激动剂的研究进展
What are the sedative effects of alpha 2 agonists?
2受体激动剂的镇静效果机理是什么？
Design and Synthesis of Novel PPARγ Agonist;
新型PPARγ受体激动剂的设计和合成
Effects of κ-Agonists on Dependece of Opioid
κ-受体激动剂在阿片依赖中的作用
Lipoxin receptor agonist BML-111 alleviates adjuvant arthritis in rats
脂氧素受体激动剂BML-111减轻佐剂诱导的关节炎
Effects of GABA_B Agonist on Cardiovascular and Respiratory Functions in Stress Rats;
GABA_B受体激动剂对应激大鼠心血管与呼吸的影响
Studies on the Analysis Method of β-Agonists in Animal Matrix;
动物组织中β-受体激动剂分析方法研究
Pharmacological Effects of New 5-HT_4 Receptor Agonist SHR116958 on Promoting Enterokinesia in Mice and Guinea Pigs
新5-羟色胺4受体激动剂SHR116958促进胃肠蠕动作用
Preparation of a Polyclonal Antiboby of Fentanyl (an Agonist of μ-Receptor)
μ受体激动剂芬太尼多克隆抗体的制备
Study on Antiasthmatic Effects of Enantiomers of SPFF, a New Selective β_2 Adrenergic Agonist;
新型β_2受体激动剂SPFF对映体的抗哮喘作用研究
Can the central sedation lead to respiratory depression?
2受体激动剂的中枢镇静能导致呼吸抑制吗？
A Phamacological Study on the Anti-Asthma Effects of SPFF,A Novel β_2 Adrenoceptor Agonist;
新型β_2受体激动剂SPFF的抗哮喘作用及机理研究
Design and Synthesis of Novel Dual-acting PPARα/γ Agonists;
新型PPARα/γ双重受体激动剂的设计与合成
Study on the Synthesis of Novel 5-HT_(1A) Receptor Agonist (±) Flesinoxan;
新型5-HT_（1A）受体激动剂（±）Flesinoxan的合成工艺研究
Synthesis and Activity Screening of β_3 Adrenergic Agonists;
β_3肾上腺素受体激动剂的合成及活性筛选
Synthesis of the Agonists of 5-HT_(2C) Receptor;
5-HT_（2C）受体激动剂小分子化合物的合成