Determination of ramipril and ramiprilat in human plasma by HPLC-MS;
液相色谱-质谱联用法同时测定人血浆中雷米普利和雷米普利拉的浓度
OBJECTIVE To establish a LC-MS-MS method for the determination of ramiprilat and its active metabolite ramiprilat in the human plasma.
目的建立LC-MS-MS法测定人血浆中雷米普利及其活性代谢产物雷米普利拉的浓度。
The serum concentrations of ramipril and its active metabolite ramiprilat were determined by HPLC-MS assay.
方法18名男性健康志愿者随机交叉po雷米普利受试制剂和参比制剂各10 mg,采用液相色谱-质谱法同时测定雷米普利及其活性代谢物雷米普利拉的药物浓度。