Research on post-translational modification of crystallins in lens;
晶状体蛋白的翻译后修饰
The p53 activity regulated by post-translational modification and localization;
蛋白质翻译后修饰及定位对p53活性的调节作用
However, many vital processes are controlled not only by the relative abundance of proteins but also by reversible post-translational modifications with specific spatial and temporal distributions.
然而,许多至关重要的生命进程不仅由蛋白质的相对丰度控制,更重要的是被那些时空特异分布的可逆翻译后修饰控制的,揭示翻译后修饰发生规律是理解蛋白质复杂多样的生物功能的一个重要前提。
This article generality discussed several questions about the post-translational modification of P53 including phosphory-lation modification, acetylation modification, smallubiquitin-like modification and the ubi.
作者针对P53的翻译后水平修饰,即磷酸化修饰、乙酰化修饰、SUMO化修饰和P53的泛素蛋白酶体降解途径等问题进行了概括性的论述,阐明了P53翻译后水平的调控网络,为进一步认识肿瘤治疗的分子机理及防治肿瘤等方面提供了理论依据。