Effects of propofol pretreatment on neurological behavior,neurofibrillary tangles and expression of GFAP in Alzheimer disease-like model rats;
异丙酚预处理对拟阿尔茨海默病模型大鼠神经行为学和神经原纤维缠结及胶质纤维酸性蛋白的影响
To investigate the effects of nerve growth factor(NGF) pretreatment on both neurofibrillary tangles(NFT) and choline acetyltransferase(ChAT) expression in the hippocampal CA1 region and parietal cortex in the Alzheimer s Disease(AD)-like model rats.
为了探讨神经生长因子(NGF)预处理对拟Alzheimer病(AD)模型大鼠海马CA1区和顶叶皮层内神经原纤维缠结(NFT)和胆碱乙酰基转移酶(ChAT)表达的影响,本研究将动物分为拟AD组和NGF预处理组。
Objective To study the effects of propofol pretreatment on learning and memory ability,and to investigate the expression of neurofibrillary tangles(NFT) and bcl-2 of hippocampus tissues in Alzheimer s disease-like model rats,and to analyze the protective effects of propofol on brain.
目的观察异丙酚预处理对拟AD模型大鼠的学习记忆功能和海马损伤神经原纤维缠结(neurofibrillary tangles,NFT)和bcl-2表达的影响,分析异丙酚的脑保护作用。
There are two main pathological hallmarkers in AD patients, one is β-amyloid peptide, the other is neurofibrillary tangles.
阿尔采末病(Alzheimesdisease,AD)是一种神经退行性病变,最近几年对AD的研究主要集中在其两个标志性的病理改变上即β样淀粉蛋白和神经纤维缠结。
Hyperphosphorylated form of tau comprises the main component of the paired helical filaments and neurofibrillary tangles found in Alzheimer s desease (AD).
Tau蛋白过度磷酸化导致Tau蛋白自我聚集成双螺旋纤维细丝 ,进而产生神经纤维缠结 ,该病理改变与阿尔采末病密切相关。
The pathological hallmarks of AD are neurofibrillary tangles,senile plaques and neuronal loss.
阿尔茨海默病(A lzhe im er’s d isease,AD)是一种发生在老年期及老年前期的神经退行性疾病,其主要的病理改变包括老年斑、神经元纤维缠结和神经元脱失。
There is a protein phosphorylation/dephosphorylation imbalance and tau is abnormally hyperphosphorylatied in the brain of patients with AD and in this form it is the major protein subunit of paired helical filaments/neurofibrillary tangles(PHF/NFT).
阿尔采末病是老年人痴呆最主要的原因 ,老年斑和神经元纤维缠结 (NFT)是其特征的病理性损伤。
The relationships between senile plaques, neurofibrillary tangles and sulfated polysaccharides;
老年斑、神经元纤维缠结与硫酸多糖
Its pathological hallmarks include amyloid plaques, neurofibrillary tangles, loss of synapes and neurons as well as brain inflammation.
阿尔采末病 (AD)是严重威胁老龄人的一类神经退行性疾病 ,其病理学特征包括 :淀粉样斑块沉积、神经元纤维缠结形成、突触和神经元的丢失以及脑内炎症。