7 kinds of organic solvents including acetonitrile, methanol, ethanol, acetone, ether, tetrahydrofuran, and isopropanol possessed non-monotone J-type dose-effect relationship, the other 13 kinds were typical S-type dose-effect relationship.
结果表明,乙腈、甲醇、乙醇、丙酮、乙醚、四氢呋喃和异丙醇7种有机溶剂具有非单调J型剂量-效应关系,其他13种为典型S型剂量-效应关系。
Objective To explore the dose-effect relationship of water fluoride levels and renal damage in children and observe the difference of renal function between high-loaded fluoride people and dental fluorosis people in the same water fluoride level region.
目的 阐明饮水氟含量与儿童肾损害的剂量-效应关系,并观察饮水氟含量相同的地区氟斑牙患者与高氟负荷人群之间肾功能有无差异。
Effects of mixed cypermethrin and methylparathion on endocrine hormone levels and immune functions in rats:Ⅰ.dose-response relationship;
氯氰菊酯和甲基对硫磷混配对大鼠内分泌和免疫系统的影响——Ⅰ.剂量-效应关系
The findings of low-dose(near or below its NOAEL)effects, as well as the non-monotonic dose-response relationship are problematic for risk assessment methods used by regulatory agencies, because they challenge the traditional use of extrapolation from high dose testing to predict responses at the much lower environmentally relevant doses which are within .
环境内分泌干扰物在接近或低于无可见不良效应浓度水平(NOAEL)时仍可诱发生物效应并存在非单调剂量-效应关系,这对现行的动物繁殖和发育毒理学检测规程以及环境内分泌干扰物风险评价的理论和方法提出了挑战。