Now, the general protocol of COH often is down-regulation treatment with GnRH agonist during mid-luteal phase which suppress the endogenous LH secretion so as to a.
我们知道发育中的卵泡如果暴露在过量的LH环境中可能会导致卵泡闭锁和正常发育的停止及并且常常提前出现LH峰导致卵子的异常成熟,目前的生殖技术控制性超排卵(controlled ovarian hyperstimulation, COH)中常规应用促性腺激素释放激素激动剂(gonadotropin releasing hormone agonist, GnRHa)垂体降调节方案就是抑制内源性LH分泌,防止过早的LH峰。
Down regulation in older women undergoing IVF-ET;
高龄不育妇女在体外受精-胚胎移植中的降调节
The Application of Different Doses of Decapeptyl Down Regulation Protocol in IVF-ET;
不同剂量的曲普瑞林降调节方案在IVF-ET中的应用